Senior Data Scientist
Amgen · Hyderabad · onsite · Posted 71d ago
Undisclosed6–11 yrsfulltimeSourced from
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About this role
What you will do
Let''s do this. Let''s change the world. We are seeking a Senior Data Scientist to join the AI & Data for Engineered Biologics team within Amgen''s Large Molecule Discovery (LMD) organization. In this vital role, you will advance data-driven prediction and design of fit-for-purpose proteins by developing machine learning models that connect sequence, structure, biophysical measurements, and experimental outcomes to biomolecular developability and structural tractability. Your work will reduce reliance on trial-and-error workflows, improve the probability of experimental success, and guide construct and condition selection for large-molecule discovery.
The successful candidate will work in a highly collaborative, multidisciplinary environment, partnering with protein scientists, structural biologists and ML engineers to support decisions from early design through sample generation and structural characterization.
KEY RESPONSIBILITIES
- Develop and apply machine learning models to predict sequence-to-property relationships.
- Develop scalable, reproducible data-processing, feature-generation, model-training, and evaluation workflows for large-scale biological datasets.
- Design, implement and train state-of-the-art foundation models including protein language models, diffusion models, or other generative approaches using multimodal biological data.
- Develop interpretable and uncertainty-aware modeling approaches that quantify confidence and support decision-making.
- Apply active learning and Bayesian optimization to guide experimental design and iterative improvement of protein design workflows.
- Collaborate cross-functionally with experimental teams to define modeling objectives, prioritize experiments, and interpret results.
- Communicate scientific findings clearly through presentations, written summaries and discussions with technical and non-technical stakeholders.
What we expect of you
We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a Senior Data Scientist with these qualifications.
Basic Qualifications
Doctorate degree with 4+yrs in Data Science, Computer Science, Computational Biology, Bioinformatics, Computational Chemistry, or a related field
Or
Master''s degree and 8+years of directly related experience
Preferred Qualifications
- Experience developing predictive machine learning models for biological, structural, biophysical, or experimental outcome data.
- Strong programming skills in Python and experience with modern machine learning frameworks such as PyTorch
- Experience with Python scientific computing tools, such as numpy, scipy, pandas, etc.
- Experience with protein language models, representation learning, transfer learning, and generative modeling.
- Experience with uncertainty estimation, model validation, calibration, and generalizability assessment across experimental conditions.
- Familiarity with active learning, Bayesian optimization, design-of-experiments, or closed-loop experimental workflows.
- Experience working with large-scale datasets and in high-performance computing environments, including cloud-based platforms (e.g., AWS)
- Familiarity with reproducible machine learning and software engineering practices, including version control (git), testing, containerization (Docker), workflow orchestration, data versioning, or experiment tracking.
- Strong scientific communication skills, with publications in leading ML, computational biology, or protein science venues such as NeurIPS, ICML, ICLR, ISMB, Nature Biotechnology , Nature Methods , Cell Systems , MABS, PNAS or comparable conferences and journals; candidates should highlight representative publications on their resume.
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Skills
modelingDockerprobabilityamazon web servicesoptimizationscienceModel ValidationScipyProgrammingPredictivePytorchworkflowBayesianPythonPandasNumpyCommunication SkillsComputer ScienceGITData ScienceMachine Learning
About Amgen
Amgen
Biotechnology
1.5k+
employees
1980
46 years old
Hyderabad, Telangana
India
About
Amgen operates in the biotechnology sector, developing and delivering advanced medicines to address critical health challenges globally.
Industries
BiotechnologyBiotech & Life sciences
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