HYDERABAD · FULLTIME
Scientist In-Vitro ADME PK
Intonation Research Laboratories
Hyderabad · onsite · Posted 2d ago
Sourced from
Undisclosed5–10 yrsfulltimeHyderabad
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Section · 01
About this role
We are currently seeking a scientist for In-Vitro - ADME to work with our agile team in Hyderabad. Intonation Research Laboratories is accelerating drug discovery and creating better therapeutics by supporting its client's chemical synthesis, biochemical and cell-based assays, and ADME-PK needs. We have assembled a diverse team with extensive experience across drug discovery disciplines. This continuum of complementary skills is essential for driving our scientific vision and needs to support our clients. We are a science-inspired, perseverant, synergistic, supportive, intrepid, and inclusive company. If you are inspired to bring better medicines to patients within a collaborative organization, then Intonation could be the right place for you.
Responsibilities
- Design and conduct in vitro ADME assays
- Plasma, Microsomal, hepatocyte, SGIF stability
- CYP inhibition/induction and phenotypic assays
- Plasma protein binding, RBS partitioning and tissue distribution
- PAMPA and Caco-2 permeability assays.
- Kinetic and thermodynamic solubility studies
- Experience in maintaining cell culture and cell banking is preferred
- In Vitro Sample processing and analysis
- Processing of in vitro assay samples by protein precipitation, solid phase extraction and their analysis using LCMS/MS
- Bioanalytical method development and validation for quantification of small molecules (NCEs/drugs/metabolites) and generic molecules as well in different biological matrices (Blood, plasma)
- Collaborate with team and project team members in troubleshooting, development and validation of new ADME cell-based assays and technologies
- Critically analyse data, interpret and communicate accurate reports, results, and ideas to team members in verbal, written, and presentation formats.
Skills
- PhD. / Postgraduate in Pharmacology with a minimum of 4-8 years of industrial experience in CRO space
- Solid understanding of in-vitro pharmacology
- Demonstrated working experience in routine assays, including but not limited to solubility assays, Hepatocyte stability assays, Plasma protein binding, permeability assays to GIF assays, and CYP inhibition Assays to demonstrate the metabolic stability enzymes
- Handling multiple projects with a result-driven approach.
- Update with scientific literature advances, developments, and regulatory guidelines in the area of drug metabolism science
- Knowledge of PK analysis using WinNonlin will be beneficial but not essential
Job Id
11009
Required Experience
4-8 years
Location
Hyderabad
Job Type
Full Time
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Disclaimer: This job posting has been aggregated from external source. Role details, content, and availability are subject to change. Applicants are advised to confirm the latest information directly on the company website before applying.
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Section · 02
Skills
AgileTroubleshootingsynthesisAssayCROpharmacologyproject teamChemistryCell CultureLCMSchemistMethod DevelopmentDrug DiscoveryplasmaBankingbioanalyticalChemical SynthesisResearchLiteratureWinNonlin