Principal Scientist- Integrated Drug Discovery
Yashraj Biotechnology · Mumbai · onsite · Posted 49d ago
Undisclosed10–15 yrsfulltimeSourced from
About a minute. You'll make an account on the way through.
About this role
- To own YBL Vision, Values and Mission.
- Reprogramming somatic cells to establish disease and healthy and disease iPSC lines, ensuring reproducibility and quality compliance throughout the process.
- Differentiating iPSC lines to target derivatives (e.g., cardiac, neural, skin cell types) using lineage-specific protocols
- Developing and validating NAM models which are Fit for Purpose and Context of Use (CoU).
- End-to-end characterization of differentiated cells including lineage marker expression by immunofluorescence, flow cytometry, and RNA/protein-based assays.
- Development and validation of CIVMs- Complex in vitro models and validation e.g. organoid, organ on chip.
- Knock in knock out studies using CRISPR technology.
- Documentation and maintenance of detailed records for all characterization assays to ensure traceability and regulatory compliance.
- Drive the QMS process as per the ISO 9001 and 13485 compliance.
- Set scientific vision and drive strategic research direction for iPSC disease modeling, differentiation technologies, and translational applications.
- Lead and mentor cross-functional teams in designing, optimizing, and scaling iPSC manufacturing and differentiation processes using cutting-edge techniques.
- Oversee process development from early-stage research to non-cGMP-ready manufacturing, ensuring scalability, compliance, and technology transfer.
- Guide project portfolio prioritization, establish milestones, and proactively manage timelines, budgets, and resources for high-impact internal and external programs
- Function as a key scientific reference, providing expert advice, troubleshooting, and decision-making support for junior and senior scientists across multiple active projects.
- Represent scientific programs at regulatory meetings, conferences, and strategic partner engagements, shaping industry standards and responding to agency inquiries.
- Champion innovation in assay development, process engineering, and automation for iPSC platforms, with a focus on next-generation manufacturing solutions.
- Take accountability for global technical alignment, troubleshooting complex scientific and operational challenges across company sites or partner collaborations.
- Foster a culture of continuous improvement and high data integrity, driving quality control, safety standards, and compliance with regulatory guidelines.
- Responsible for ALCOA+++ and GMP compliance practices.
Disclaimer: This job posting has been aggregated from external source. Role details, content, and availability are subject to change. Applicants are advised to confirm the latest information directly on the company website before applying.
Sourced from naukri
Skills
data integrityAutomationTroubleshootingContinuous improvementManager Quality Controlprocess engineeringFlow CytometryGMPoperationscompliance
About Yashraj Biotechnology
Yashraj Biotechnology
Biotechnology
201
employees
1999
27 years old
Mumbai,Maharashtra
India
₹4.8L PA avg
Avg at Yashraj Biotechnology
About
Yashraj Biotechnology engages in research and innovation in the biotech sector, maintaining high certifications and an international presence.
Industries
BiotechnologyPharma
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10 reviews
3.5/ 5
Culture
3.6
Career growth
2.2
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