Principal Project Scientist-Cancer Biology & Multi-omics

Role Summary

We are seeking an experienced Senior Cancer Biologist to spearhead a multidisciplinary team

dedicated to the histological and molecular profiling of solid tumours. This leadership role drives

the integration of high-resolution 3D histology, liquid biopsy, and multiomics to decode complex

tumor microenvironments, with a specific focus on the unique molecular landscape of Indian

cohorts. The successful candidate will direct end-to-end wet-lab and computational workflows,

translating cutting-edge histological and spatial omics into actionable oncological insights.

About the Centre

The Centre for 3D Cancer is a Focused Research Organization dedicated

to advancing multidisciplinary digital tissue mapping and high-resolution histopathology in

oncology. Operating at the intersection of clinical research, tissue imaging, advanced molecular

biology, and computational science, we are committed to decoding complex tumor

microenvironments at unprecedented scales. Our state-of-the-art infrastructure seamlessly

integrates advanced 3D histology, multiomics, spatial biology and liquid biopsy pipelines to drive

deep molecular profiling. By specifically focusing on the unique genomic and clinical landscapes

of Indian cohorts, the Centre for 3D Cancer Omics translates complex molecular data into

actionable insights, pushing the boundaries of precision oncology and transformative cancer

care.

Key Responsibilities

The primary responsibility is to direct and mentor a cross-functional research team executing

advanced 3D digital histopathology, spatial transcriptomics and other multi-omics along with

computational analysis.

• The lead will architect robust experimental pipelines for 3D tissue mapping and liquid

biopsy assays, ensuring the seamless integration of molecular data with

histopathological findings.

• Core daily functions include managing facility operations, overseeing high-throughput

data generation, and driving methodological innovations.

• Additionally, this role requires adept resource allocation, the drafting of comprehensive

research proposals, and close collaboration across clinical, wet-lab, and computational

biology teams.

• Lead the entire multidisciplinary team toward achieving impactful translational outcomes

in oncology, effectively bridging basic research and clinical applications to accelerate

translatable innovations in precision oncology.

Required Qualifications & Skills

• Candidates must possess a minimum of five years of post-doctoral or industry

experience in solid tumor oncology, molecular biology, or a closely related discipline,

paired with a proven track record of team leadership.

• Exceptional proficiency in navigating the intersection of digital histopathology and

multiomics is mandatory.

• The role demands strong strategic planning capabilities to successfully execute

multi-phase research projects, guiding efforts from initial tissue processing through to

final multi-omic data integration.

Educational Background

A Ph.D. in Cancer Biology, Molecular Genetics, Genomics, or a highly related scientific

discipline from a reputed institute and 7+ years of post-doctoral or industry experience in solid

tumor oncology.

Technical & Lab Expertise

• Expertise in establishing and optimizing digital histopathology pipelines, NGS workflows

and diverse molecular probing methods that extend beyond standard commercial kits.

• Extensive experience with liquid biopsy protocols, spatial transcriptomics platforms, and

histopathology environments is required.

• Furthermore, familiarity with bioinformatics tools and open-source software for cancer

image analysis, multiomics data analysis and interpretation.

Soft Skills & Operational Drive

• We require a driven leader capable of cultivating a collaborative, multidisciplinary

environment while upholding rigorous scientific standards.

• The candidate must be able to translate and communicate effectively across distinct

biological and computational units.

• Exceptional organizational drive is essential to oversee facility procurement, manage

continuous operational workflows, and mentor early-career researchers and scholars.

Desirable / Preferred Qualifications

• Prior experience establishing or managing a specialized molecular oncology or

histopathology core facility stands as a significant advantage.

• A deep familiarity with solid tumor pathology, NGS, biomarker analysis and validation,

spatial biology platforms, and a proven ability to adapt diverse multiomics techniques to

novel research strategies are highly preferred.