Principal Data Scientist

Career Category Engineering Job Description Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Principal Data Scientist

What you will do We are seeking a Principal Data Scientist to join the Forecasting team, within the AI & Data organization. This role will lead the development of advanced statistical, Bayesian, causal, and machine learning models that improve forecasting capabilities and quantify uncertainty to guide strategic decision making across the company.

This leader will partner across Commercial, Operations, Supply Chain, Manufacturing, Finance, and Technology to build forecasting technology that support critical business processes, ensuring Amgen delivers on its “every patient, every time” mandate. The role is particularly suited to a creative problem solver who is excited about leveraging state of the art forecasting methods, complex high-dimensional data sources, and agentic development practices to build decision-support tools that connect demand signals with supply constraints, enabling reliable, risk-adjusted scenario planning across short-, mid-, and long-range horizons.

Key Responsibilities Develop advanced statistical, Bayesian, and machine learning models to forecast demand across multiple horizons, including near-, medium-, and long-term planning horizons.

Work with large, complex data sets, leveraging state of the art techniques in statistical modeling, causal inference and analytics to generate insights that support strategic decision making across the business.

Develop high fidelity simulation and scenario evaluation capabilities to understand the complex dynamics between patients, payers and providers.

Own the end-to-end modeling lifecycle, including scoping, prototyping, data analysis, feature engineering, model development, deployment and, monitoring as well as explainability.

Architect and develop self-service forecasting tools and platforms, ensuring leadership can act on near real-time predictions.

Collaborate with cross functional teams in Commercial, Operation, Finance and Technology to ensure forecasts are well integrated into critical business workflows.

Develop a holistic understanding of Amgen’s systems and processes in relation to industry challenges and broader trends to identify opportunities and risks.

Research and evaluate emerging tools and methodologies in forecasting, data science and AI.

Establish forecasting as an advanced, rigorous practice across the organization and upskill and mentor junior team members.

Basic Qualifications Bachelor’s degree and 12 years of data science in enterprise environments experience OR

Associate’s degree and 14 years of data science in enterprise environments experience OR

High school diploma / GED and 16 years of data science in enterprise environments experience

Preferred Qualifications 12+ years of experience applying data science in enterprise environments with demonstrated principal-level influence or equivalent depth of expertise.

Deep expertise in time-series forecasting, probabilistic programming, Bayesian and predictive modeling, with practical experience delivering models that drive business measurable value.

Expert understanding of Python, SQL and tools such as scikit-learn, PyMC, Pytorch, Tensorflow and other data science libraries.

Strong communication and story-telling skills, with ability to explain complex technical concepts and influence executive level decision making.

Exceptional stakeholder management with ability to drive alignment on , relationships, and metrics, and communicate tradeoffs clearly.

An intellectually curious self-starter who can take ambiguous problems and build robust solutions from 0 to 1.

Experience building and scaling forecasting platforms for biotech/pharma use cases and knowledge of healthcare commercial concepts such as payer/provider dynamics, formulary access, and coverage.

Experience leveraging machine learning, operations research algorithms, and statistical modeling for retail, consumer goods, supply chain or manufacturing applications

Deep expertise in causal inference, Bayesian forecasting, and hierarchical or multi-level forecasting methods.

Familiarity with ML Ops, CI/CD, and engineering best practices that enable scalable deployment and adoption of forecasting products.

What You Can Expect Of Us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

Salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts

A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan

Stock-based long-term incentives

Award-winning time-off plans

Flexible work models, including remote and hybrid work arrangements, where possible

Apply now for a career that defies imagination Objects in your future are closer than they appear. Join us. careers.amgen.com

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. We will ensure that individuals with disabilities are provided with reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request an accommodation. 

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