Opening For R&D Crystallization

Role & responsibilities

Company: MSN Laboratories Pvt. Ltd.
Department: Research & Development API
Experience: 2–5 Years
Qualification: M.Sc. in Organic Chemistry

Job Summary

We are looking for a skilled R&D professional with 2–5 years of experience in crystallization, isolation, and purification of Active Pharmaceutical Ingredients (APIs) and intermediates. The candidate will be responsible for developing and optimizing crystallization processes to achieve the desired purity, yield, particle size, and solid-state properties.

Key Responsibilities

• Develop and optimize crystallization and recrystallization processes for APIs and intermediates.
• Perform solvent screening and identify suitable solvent and anti-solvent systems.
• Conduct solubility studies, temperature profile studies, and supersaturation assessments.
• Optimize process parameters such as temperature, cooling rate, agitation, seeding, concentration, and aging time.
• Perform polymorph screening and evaluate solid-state properties, where required.
• Improve product yield, purity, filterability, and drying characteristics.
• Execute laboratory experiments involving crystallization, filtration, washing, and drying.
• Characterize crystalline products using analytical techniques such as HPLC, XRPD, DSC, TGA, and particle-size analysis, as applicable.
• Troubleshoot issues such as oiling out, precipitation, agglomeration, poor filtration, and inconsistent crystal formation.
• Support process development, scale-up, and technology transfer activities.
• Prepare experimental protocols, laboratory notebooks, technical reports, and process development documentation.
• Follow laboratory safety procedures, GMP requirements, and applicable EHS guidelines.

Required Skills

• Hands-on experience in crystallization and recrystallization process development.
• Knowledge of solvent selection, solubility, supersaturation, nucleation, and crystal growth.
• Understanding of API isolation and purification techniques.
• Familiarity with polymorphism and solid-state characterization.
• Knowledge of HPLC and other analytical techniques used for product characterization.
• Ability to analyze experimental data, troubleshoot process issues, and optimize process parameters.
• Good documentation, communication, and teamwork skills.

Preferred Experience

• Experience in pharmaceutical API process R&D.
• Exposure to scale-up of crystallization processes from laboratory to pilot scale.
• Familiarity with particle engineering, crystal morphology, and polymorph control.
• Experience working in a regulated pharmaceutical R&D environment.

Eligibility

• 2–5 years of relevant experience in crystallization R&D, API process development, or pharmaceutical process chemistry.
• M.Sc. in Chemistry