Downstream Production and Manufacturing

Job Purpose

Responsible for leading and executing unit operations in downstream processing for enzyme extraction and purification, operating specialized recovery and drying equipment, maintaining GMP compliance, and achieving yield targets while adhering to plant safety standards.

Key Responsibilities

• Unit Operations Management: Independently operate and supervise downstream processing equipment, including production Reactors, Filter Presses, Microfiltration (MF), Ultrafiltration (UF) systems, and industrial Centrifuges.
• Drying & Powder Processing: Oversee final product drying operations using Spray Dryers, Rotary Vacuum Paddle Dryers (RVPD), and Flash Dryers to achieve required moisture specifications.
• Enzyme Extraction & Recovery: Execute cell lysis, solid-liquid separation, concentration, precipitation, and enzyme isolation protocols to optimize product yield and purity.
• Process Optimization & Yield Tracking: Monitor key process parameters (pH, temperature, pressure, flux rate, flow rates) during filtration and concentration phases to minimize product loss.
• Batch Documentation: Complete Batch Manufacturing Records (BMR), Batch Execution Logs, equipment logbooks, and SOPs in full compliance with quality and regulatory standards.
• Equipment Maintenance & Sanitation: Perform standard Cleaning-In-Place (CIP) and Sterilization-In-Place (SIP) routines; assist engineering teams in preventive maintenance and troubleshooting.
• EHS & Quality Compliance: Adhere to plant safety protocols, handling hazardous chemical reagents safely, and maintaining cleanroom/production floor hygiene under cGMP norms.

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