Director, Medical Science Liaison - Epilepsies

Location:   This position may be performed remotely, but requires the flexibility and willingness to travel as needed.

The Opportunity

Praxis is seeking a Director, Medical Science Liaisons to lead and develop the field medical team supporting our epilepsy portfolio, including relutrigine, through pre-launch and launch. Reporting to the Head of Field Medical Affairs, this people-leadership role is responsible for hiring, coaching, and developing a high-performing team of Medical Science Liaisons (MSLs); translating medical strategy into a compliant, high-impact field medical plan; and ensuring consistent, high-quality scientific exchange across a defined set of high-priority academic and community neurology centers.  

This is a field-based leadership role operating within a highly focused engagement model in rare and developmental epilepsies. Along with the Head of Field Medical Affairs, you will set the direction for the MSL team’s scientific engagement, oversee KOL and center prioritization and territory alignment, and ensure the team communicates emerging clinical data accurately and compliantly while surfacing meaningful field insights that shape strategy.  

Working in close Praxis partnership, you will champion aligned execution of pre-launch and launch activities and serve as a key bridge between field intelligence and medical strategy in a dynamic, evolving environment.  

Success in this role requires proven people-leadership, strong scientific acumen, sound judgment, and the ability to build and inspire a team that engages credibly in complex clinical discussions while operating with independence in the field.  

Primary Responsibilities

Lead, coach, and develop a high-performing team of epilepsy MSLs, setting clear objectives, performance expectations, and individual development plans   

Build and scale a high-performing Field Medical organization, including workforce planning, succession planning, talent assessment, onboarding strategy, and capability development  

Establish field medical operating standards, performance expectations, and excellence frameworks to ensure consistent execution and scientific credibility across the team  

Lead territory design, resource allocation, and organizational planning to ensure optimal coverage of key centers, investigators, and stakeholders throughout pre-launch and launch  

Translate Medical Affairs strategy into an actionable field medical plan, including engagement priorities, scientific objectives, and team success metrics   

Oversee KOL and center engagement strategy, territory alignment, and account planning across priority academic and community neurology centers   

Ensure the team delivers accurate, balanced, and compliant scientific exchange on disease state, clinical data, and the relutrigine clinical profile in rare and genetic epilepsies   

Build team capability and readiness for pre-launch and launch, including onboarding, scientific training, and field coaching on SCN2A, SCN8A, and broader epilepsy populations   

Aggregate, synthesize, and elevate field insights to inform medical, clinical, and commercial strategy, and report on field medical activity and impact   

Partner cross-functionally with internal Praxis leadership to ensure aligned execution   

Represent Field Medical Affairs at scientific congresses, advisory boards, and internal governance forums   

Manage field medical operations, including CRM utilization, metrics and reporting  

Establish, monitor, and enforce compliance with regulatory requirements, company policies, SOPs, and industry standards across all field activities  

Maintain current expertise in the rare epilepsy landscape, competitive environment, and evolving treatment paradigms, and ensure the team stays scientifically current  

Qualifications and Key Success Factors

Advanced clinical or scientific degree (PharmD, PhD, or MD; NP, PA, or RN with relevant experience)   

Substantial Medical Affairs / MSL experience in biotech or pharma, including demonstrated people-leadership or field-management experience   

Proven success leading geographically dispersed field medical teams, including experience managing managers and/or leading organizations through periods of growth, transformation, or launch   

Experience establishing field medical strategy and operating models in pre-launch and launch environments  

Demonstrated ability to influence senior executives and drive cross-functional alignment without direct authority  

Experience supporting Market Access initiatives, including Managed Care strategy, payer engagement, and reimbursement activities  

Experience managing budgets, headcount planning, and organizational resource allocation  

Strong scientific acumen with the ability to coach the team through complex clinical and data discussions in rare patient populations   

Demonstrated ability to translate medical strategy into field execution and measurable results   

Experience in neurology or CNS disorders required; rare or genetic epilepsy experience strongly preferred   

Product launch and pre-launch experience strongly preferred   

Excellent cross-functional leadership, influence, and communication skills  

Ability to manage competing priorities, budgets, and resources with strong organization and attention to detail  

Willingness to travel up to ~75%, including field co-travel, scientific congresses, and internal meetings  

The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement.  You'll need comfort with screen work, basic hand coordination, and focus.  Reasonable accommodations may be made to enable individuals with disabilities to perform these functions.

 

Compensation & Benefits

At Praxis, we believe that taking care of our people (and their people) is important, so we provide a world class benefits package to help you thrive.  This includes 99% of the premium paid for medical, dental and vision plans.  We also provide company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. Thinking about the future?  We match dollar-for-dollar up to 6% on eligible 401(k) contributions and sweeten the deal with long-term stock incentives and ESPP.  We provide a discretionary quarterly bonus, an extremely flexible wellness benefit, generous PTO, paid holidays and company-wide shutdowns.  Not to mention, you'll also be joining a phenomenal crew of colleagues who are smart, engaged and inspiring.  We aim high, collaborate hard, and produce results.  Let’s achieve the impossible together! 

To round out our world-class total rewards package, we provide annualized base salary compensation in the range listed below.  This range reflects the base salary the Company reasonably expects to pay for the position at the time of posting. Placement within the range will be based on job-related factors, including experience, qualifications, scope of responsibilities, and demonstrated track record of delivering results in similar roles. Annualized Base Salary $230,000 — $250,000 USD

Company Overview  

Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance.  At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders.  Our core Values of Trust , Ownership , Curiosity and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members.

Diversity, Equity & Inclusion Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE ® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws.

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