Chemist / Senior Chemist - Oligonucleotide Chemistry : Jubilant Biosys

Job Description:

Position: Chemist / Senior Chemist

Location: Nanjangud / Mysore, Karnataka

Experience: 2-8 Years

Qualification

• M.Sc. (Organic Chemistry / Medicinal Chemistry) or M. Pharm.
• Candidates with industrial experience in basic oligonucleotide, nucleoside, nucleotide, or phosphoramidite chemistry will be preferred.

Job Summary

The Chemist/Senior Chemist will be responsible for the synthesis, purification, characterization, and process development of basic oligonucleotide intermediates, phosphoramidites, nucleosides, and related specialty chemicals. The role involves laboratory execution, process scale-up support, technology transfer, documentation, and adherence to safety and quality requirements.

Key Responsibilities

Oligonucleotide & Phosphoramidite Chemistry

• Synthesize nucleoside intermediates and phosphoramidites.
• Execute DMT protection/deprotection, phosphitylation, and chromatography processes.
• Handle moisture-sensitive reagents such as phosphoramidites, phosphorus chlorides, CEP reagents, and activators.
• Support oligonucleotide synthesis, cleavage, deprotection, and purification activities.
• Assist in process development and optimization for amidites and oligonucleotide building blocks.

Laboratory Operations

• Plan and execute reactions from milligram to gram scale.
• Operate reactors, rotary evaporators, vacuum systems, filtration and drying equipment.
• Perform reaction monitoring using TLC, HPLC, UPLC, GC, KF, and NMR interpretation.
• Maintain laboratory notebooks and experimental records.

Process Development

• Conduct route scouting and process optimization studies.
• Identify critical process parameters and process risks.
• Support technology transfer and scale-up from laboratory to pilot plant/manufacturing.
• Prepare process descriptions, batch records, and development reports.

Documentation & Compliance

• Maintain GMP-compliant documentation where applicable.
• Prepare SOPs, risk assessments, and technical reports.
• Ensure compliance with EHS, quality, and data integrity requirements.