Associate Director, Portfolio Operations and Insights

Position Summary:

The Associate Director of R&D Portfolio Operations & Insights will drive the design, standardization, and continuous improvement of portfolio management processes across the R&D organization.

This role is responsible for enabling integrated planning, improving predictability, and driving portfolio transparency through scalable PMO frameworks, data infrastructure, analytics, and reporting - including robust financial modeling, budget governance, and investment performance tracking. This individual will serve as a strategic operations partner to R&D, Finance, and PMO Leadership, ensuring there is a single-source of truth to enable portfolio insights and decisions.

Key Responsibilities:

Portfolio Governance & PMO Standardization

Design and implement standardized PMO processes, tools, and governance frameworks across R&D.

Establish integrated planning processes that connect strategy, resource planning, timelines, and execution milestones.

Drive adoption of best practices for stage-gate governance, risk management, and cross-functional alignment.

Lead continuous improvement initiatives to enhance operational rigor, predictability, and accountability.

Budget Governance & Financial Modeling

Establish phase-appropriate budget frameworks for projects at each stage-gate, defining level of estimate rigor

Define and maintain a standardized process for project budget creation, baseline-setting, and adjustment ensuring consistency in how budgets are structured and tracked across the portfolio

Implement mechanisms to measure and report budget adherence at the project level, including variance analysis, earned value metrics, and escalation thresholds for material deviations

Partners with Finance to align on capitalization and expense treatment, ensure accurate project cost coding and support close and accrual processes 

Support business case development by providing standardized templates NPV/ IRR modeling, and scenario analysis

Portfolio Management Systems & Data Infrastructure

Own and evolve the R&D portfolio management database, ensuring data accuracy, integrity, and usability.

Define data standards, KPIs, and portfolio health metrics including financial KPIs such as cost-to-market, forecast accuracy, and budget accuracy.

Lead vision for automated dashboards and trending analyses to provide real-time insights to leadership.

Enable scalable reporting capabilities through tools and systems optimization.

Portfolio Insights, Prioritization & Reporting

Create portfolio views to support investment decisions, resource allocation, and strategic trade-offs.

Work with PMO portfolio leads to develop executive-ready reporting packages (monthly/quarterly) highlighting progress, risks, financial performance and trends.

Translate complex data into clear, actionable insights for senior stakeholders.

QUALIFICATIONS:

Bachelor’s degree in Biology or equivalent.  MS or PhD in Biological Sciences preferred.

Minimum of 10 years of program management experience in biotech space and educational background in molecular biology or genetics testing.

Experience as FP&A or Finance Manager supporting Engineering or Product organizations desirable.

Certification or formal training in Program or Project Management and experience using resource management tools is a big plus.

KNOWLEDGE, SKILLS, AND ABILITIES:

Strong knowledge of creative workflows, project management tools and processes.

Experience compiling GANTT charts and project plans.

Experience with product development.

Familiar with design control is a plus.

Proficiency in financial modeling, budget management, and portfolio financial analysis; experience with NPV, cost-to-market, and forecast accuracy methodologies.

Comfort working with large datasets and financial systems; experience with portfolio management platforms (e.g., Planisware, Smartsheet, Oracle, SAP) and BI tools (e.g. Tableau, Power BI) is a plus.

Excellent interpersonal skills and the ability to establish and build productive relationships.

Excellent communication within the project teams as well as with diverse stakeholders, including top level management.

Excellent organization and time management/multi-tasking skills (comfortable in an ambiguous and fast-paced environment, operating at both strategic and tactical levels).

Compensation & Total Rewards 

This range reflects a good-faith estimate of the base pay we reasonably expect to offer at the time of  hire. Final compensation will vary based on experience, qualifications, and internal equity considerations.

This position is also eligible for additional compensation and benefits through Natera’s robust Total Rewards program, including:

Annual performance incentive bonus

Long-term equity awards

Comprehensive health benefits (medical, dental, vision)

401(k) with company match

Generous paid time off and company holidays

Additional wellness and work-life benefits

Compensation Range $155,700 — $200,000 USD

OUR OPPORTUNITY

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.

WHAT WE OFFER

Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!

For more information, visit www.natera.com .

Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.

All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.

If you are based in California, we encourage you to read this important information for California residents. 

Link: https://www.natera.com/notice-of-data-collection-california-residents/

Please be advised that Natera will reach out to candidates with a @ natera.com  email domain ONLY. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes.

For more information:

• BBB announcement on job scams  
• FBI Cyber Crime resource page