Analytical R&D - Solid State Characterization

Role & responsibilities

Solid-State Analysis

• Perform solid-state characterization of APIs, intermediates, reference standards, and impurities.
• Conduct polymorph screening, salt/co-crystal screening, and crystal form identification studies.
• Investigate phase transformations, hygroscopicity, and stability-related solid-state changes.
• Support process development teams in crystallization process optimization and scale-up studies.

Analytical Techniques

Hands-on operation, troubleshooting, and interpretation of data from:

• XRPD (X-Ray Powder Diffraction)
• DSC (Differential Scanning Calorimetry)
• TGA (Thermogravimetric Analysis)
• DVS (Dynamic Vapor Sorption)
• Hot Stage Microscopy (HSM)
• Polarized Light Microscopy (PLM)
• Raman Spectroscopy
• FTIR Spectroscopy
• Particle Size Analysis
• Surface Area Analysis (BET) (preferred)

Technical Support

• Characterize unknown solid forms and investigate product quality issues.
• Provide scientific interpretation and recommendations based on solid-state data.
• Collaborate with AR&D, PR&D, QA, QC, and Regulatory teams.
• Support client projects involving polymorphism, crystallization, and solid-state investigations.
• Strong knowledge of polymorphism, crystallization, phase transitions, and solid-state chemistry.
• Experience in interpretation of XRPD, DSC, TGA, DVS, microscopy, Raman, and FTIR data.
• Strong report writing and scientific presentation skills.